Circuit-based mechanisms of affective processing
Summary
Here, we explore how altered circuit function in the basolateral amygdala (BLA) contributes to impaired valence processing and affective dysfunction in mental illnesses.
Key Highlights
- Redefined valence computations and affective processing through the lens of neural circuit dynamics.
- Highlighted the role of the basolateral amygdala (BLA) as a central hub for valence computation and affective processing across species.
- Proposed a mechanism by which biased information routing promotes negative affective states.
- Investigated the relationship between oscillatory dynamics, mental disorders, and altered affective states.
Authors:
Pantelis Antonoudiou, Eric Teboul, Kenneth A. Amaya, Bradly T. Stone, Kaitlyn E. Dorst, Jamie L. Maguire
🔗 Read the paper (Biological Psychiatry) 📖 Available Open Access on PMC: PMCID: PMC11954678 (Available 2026-04-15)